Takotsubo cardiomyopathy in two patients with microvascular angina

We present two cases in which takotsubo cardiomyopathy (TC) developed immediately after a diagnosis of microvascular angina had been established. One patient who had been diagnosed as having endothelium-dependent microvascular angina (microvascular spasm) developed TC three weeks after the initial admission. The other patient was diagnosed as having endothelium-independent microvascular angina (decreased coronary flow reserve) and subsequently developed TC after the discontinuation of nicorandil treatment. These cases may provide insight into the possible mechanisms underlying the pathophysiological findings of TC. <Learning objective: Impaired coronary microcirculation has been recently reported in many cases during the acute phase of takotsubo cardiomyopathy. However, the exact mechanism responsible for the coronary microvascular dysfunction associated with this entity remains unclear. This report highlights the importance of microvascular angina, which may play a role in the development of this cardiomyopathy.>.