Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peroxisomes and Mitochondria01:30

Peroxisomes and Mitochondria

95.4K
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
95.4K
Peroxisomes01:24

Peroxisomes

21.1K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
21.1K
Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

5.4K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
5.4K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.6K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.6K
X-linked Traits01:19

X-linked Traits

58.6K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
58.6K
Gastric Motility01:16

Gastric Motility

3.2K
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities.

Nature communications·2026
Same author

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox.

Science (New York, N.Y.)·2025
Same author

Profiling the LAM Family of Contact Site Tethers Provides Insights into Their Regulation and Function.

Contact (Thousand Oaks (Ventura County, Calif.))·2025
Same author

Integrated proteome and lipidome analyses place OCIAD1 at the mitochondria-peroxisome intersection balancing lipid metabolism.

Journal of cell science·2025
Same author

Modelling Peroxisomal Disorders in Zebrafish.

Cells·2025
Same author

Organelle Membrane Extensions in Mammalian Cells.

Biology·2023

Related Experiment Video

Updated: Feb 1, 2026

Gastrointestinal Motility Monitor GIMM
08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 1, 2010

31.5K

Miro1 - the missing link to peroxisome motility.

Inês G Castro1, Michael Schrader2

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Communicative & Integrative Biology
|December 12, 2018
PubMed
Summary

Miro1 regulates peroxisome movement in mammalian cells by interacting with Pex19. Three studies identified Miro1

Keywords:
Miro1actinmicrotubuleorganelle motilityperoxisome

More Related Videos

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.8K
Measuring Crop Motility and Food Passaging in Drosophila
06:13

Measuring Crop Motility and Food Passaging in Drosophila

Published on: May 9, 2020

6.3K

Related Experiment Videos

Last Updated: Feb 1, 2026

Gastrointestinal Motility Monitor GIMM
08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 1, 2010

31.5K
Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.8K
Measuring Crop Motility and Food Passaging in Drosophila
06:13

Measuring Crop Motility and Food Passaging in Drosophila

Published on: May 9, 2020

6.3K

Area of Science:

  • Cell Biology
  • Organelle Dynamics
  • Molecular Mechanisms

Background:

  • Peroxisomes are vital organelles involved in lipid metabolism and redox balance.
  • Peroxisome motility is crucial for cellular functions and division.
  • Knowledge of peroxisome movement in mammalian cells is limited.

Purpose of the Study:

  • To investigate the role of Miro1 in mammalian peroxisome motility.
  • To understand the mechanism of Miro1 targeting to peroxisomes.

Main Methods:

  • Utilized mammalian cell lines.
  • Investigated protein interactions between Miro1 and Pex19.
  • Analyzed peroxisome targeting and motility.

Main Results:

  • Miro1 is targeted to peroxisomes in multiple mammalian cell lines.
  • Miro1 targeting depends on its interaction with the peroxisomal chaperone Pex19.
  • Discrepancies exist regarding Miro1 isoforms and motility regulation.

Conclusions:

  • Miro1 is a key regulator of peroxisome motility in mammalian cells.
  • The interaction with Pex19 is essential for Miro1 peroxisomal localization.
  • Further research is needed to clarify Miro1 isoform specificity and precise motility roles.