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Related Concept Videos

Virtual Work01:20

Virtual Work

1.4K
The principle of virtual work states that if a body is in static and dynamic equilibrium, then the sum of all the virtual work done by all external forces and couple moments for any given virtual displacement must be zero.
In static equilibrium, a body can experience an imaginary or virtual movement, such as displacement or rotation. The virtual work done by a force is equal to the dot product of force and virtual displacement in the direction of the force. When it comes to virtually rotating a...
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Design Example: Designing Water Slide01:18

Design Example: Designing Water Slide

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When designing a water slide, controlling the speed of water flow is crucial for rider safety while maintaining an exciting experience. As water flows down the slide, gravity causes it to accelerate, with its speed at the bottom depending on the height from which it starts. The higher the slide, the more potential energy the water has at the top, which is converted into kinetic energy as it descends, increasing its speed.
Bernoulli's principle determines the water's velocity along the slide....
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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Principle of Virtual Work: Problem Solving01:13

Principle of Virtual Work: Problem Solving

1.7K
The principle of virtual work is an essential concept in the field of mechanics and engineering. This is used to solve problems related to the equilibrium of a structure or system. It is based on the assumption that if a system is in equilibrium, the work done by all the forces during a virtual displacement is zero. This principle is applied by considering virtual displacements of the system and the corresponding work done by internal and external forces.
To apply the principle of virtual work,...
1.7K
Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Virtual Work for a System of Connected Rigid Bodies01:06

Virtual Work for a System of Connected Rigid Bodies

754
Virtual work is a powerful method used to solve problems involving several connected rigid bodies. When the system is in equilibrium, virtual work is zero. This allows the calculation of the resulting forces when a system undergoes a virtual displacement. When attempting to analyze such a system, first, use a free-body diagram, where an independent coordinate represents the configuration of the links, and mark its deflected position resulting from the positive virtual displacement.
Next,...
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High-Speed Ultraviolet Photoacoustic Microscopy for Histological Imaging with Virtual-Staining assisted by Deep Learning
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Digital Microscopy, Image Analysis, and Virtual Slide Repository.

Famke Aeffner1, Hibret A Adissu1, Michael C Boyle1

  • 1Famke Aeffner, DVM PhD DACVP, is a principal pathologist in the Comparative Biology and Safety Sciences Department at Amgen Inc. in South San Francisco, California. Hibret Adissu, DVM PhD DVSc DACVP, is an investigative pathologist in the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, at the National Cancer Institute in Bethesda, Maryland. Michael C. Boyle, DVM PhD DACVP DABT, is a principal pathologist in the Comparative Biology and Safety Sciences at Amgen Inc. in Thousand Oaks, California. Robert D. Cardiff, MD PhD, is a distinguished professor of pathology (emeritus) at the Center for Comparative Medicine at the University of California in Davis, California. Erik Hagendorn is a senior scientist of informatics at AbbVie Bioresearch in Worcester, Massachusetts. Mark J. Hoenerhoff, DVM PhD DACVP, is an associate professor and veterinary pathologist at the In Vivo Animal Core, Unit for Laboratory Animal Medicine, at the University of Michigan in Ann Arbor, Michigan. Robert Klopfleisch, DVM PhD DACVP, is an associate professor at the Institute of Veterinary Pathology of the Freie Universitaet Berlin, in Berlin, Germany. Susan Newbigging, BSc MSc DVM DVSc, is a pathologist and Director of The Pathology Core at the Toronto Center of Phenogenomics in Toronto, Ontario, Canada. Dirk Schaudien, DVM PhD DACVP, is a veterinary pathologist at the Fraunhofer Institute for Toxicology and Experimental Medicine, in Hannover, Germany. Oliver Turner, BSC(Hons), BVSc MRCVS PhD DACVP DABT, is a senior pathologist in the Preclinical Safety department of Novartis Pharmaceuticals in East Hanover, New Jersey. Kristin Wilson, DVM PhD DACVP, is a pathologist at Flagship Biosciences Inc. in Westminster, Colorado.

ILAR Journal
|December 12, 2018
PubMed
Summary
This summary is machine-generated.

Digital microscopy and whole slide imaging revolutionize tissue research by enabling digital slide sharing and quantitative image analysis. This technology enhances data extraction and collaboration in pathology workflows.

Keywords:
deep learningimage analysisslide repositoryslide scannerstereologyvirtual microscopywhole-slide imagingwhole-slide scanning

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Area of Science:

  • Digital pathology
  • Computational pathology
  • Histopathology imaging

Background:

  • Technological advancements facilitate digital microscopy and image analysis for tissue-based research.
  • Whole slide imaging (WSI) digitizes histology slides for virtual repositories, enabling computer-based viewing.
  • Digital slides offer advantages like improved image sharing, storage, and feature annotation.

Purpose of the Study:

  • To introduce digital microscopy and pathology concepts.
  • To address technical and scientific considerations in digital slide scanning, quantitative image analysis, and repositories.
  • To highlight the current state of digital pathology technology and its optimal utility.

Main Methods:

  • Review of digital microscopy technologies and applications.
  • Discussion of slide scanning, digital image analysis software, and virtual slide repositories.
  • Consideration of preanalytical factors and pathologist involvement in digital workflows.

Main Results:

  • Digital microscopy enables efficient sharing, storage, and analysis of histologic images.
  • Quantitative image analysis tools extract valuable data from digital slides.
  • Integration of digital pathology streamlines research and diagnostic processes.

Conclusions:

  • Digital microscopy and WSI offer significant advantages for tissue-based research and pathology.
  • Careful consideration of technical and preanalytical factors is crucial for optimal implementation.
  • Pathologist involvement is essential throughout the digital pathology workflow for successful adoption.