EQ-5D-5L Valuation for the Malaysian Population

Area of Science:

• Health Economics
• Patient-Reported Outcomes
• Psychometrics

Background:

• The EQ-5D-5L is a widely used instrument for measuring health status.
• Developing country-specific value sets is crucial for accurate health economic evaluations.
• Previous value sets may not accurately reflect Malaysian population preferences.

Purpose of the Study:

• To develop a robust EQ-5D-5L value set for the Malaysian adult population.
• To ensure the value set accurately captures health state preferences within Malaysia.
• To provide a tool for health technology assessment (HTA) and research in Malaysia.

Main Methods:

• A representative sample of 1125 Malaysian adults was recruited using quota sampling.
• Data were collected using the EuroQol Valuation Technology (EQ-VT) system.
• Composite time trade-off (C-TTO) and discrete choice experiment (DCE) tasks were administered.
• Constrained regression models, including hybrid C-TTO and DCE data, were explored for value set prediction.

Main Results:

• An eight-parameter hybrid model combining C-TTO and DCE data demonstrated superior predictive accuracy.
• This model showed better out-of-sample prediction and more precise estimates compared to C-TTO-only models.
• The resulting Malaysian EQ-5D-5L value set ranges from -0.442 to 1.

Conclusions:

• The constrained eight-parameter hybrid model is suitable for representing the Malaysian EQ-5D-5L value set.
• This new value set will enhance the validity of HTA and research applications in Malaysia.
• It provides a culturally relevant measure of health preferences for the Malaysian population.