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Role and mechanism of Dvl3 in the esophageal squamous cell carcinoma

X-Q Chen1, J Jiang, X-T Wang

  • 1Department of Gastroenterology, First Affiliated Hospital of Henan University of TCM, Henan, China. jqmy858384@163.com.

European Review for Medical and Pharmacological Sciences
|December 12, 2018
PubMed
Abstract

Insights

Dishevelled-3 (Dvl3) is elevated in esophageal squamous cell carcinoma, promoting tumor growth and metastasis. Silencing Dvl3 inhibits cancer progression, offering potential for diagnosis and therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Esophageal squamous cell carcinoma (ESCC) is a significant global health concern.
  • Dishevelled-3 (Dvl3) is a key component of the Wnt signaling pathway, implicated in various cancers.

Purpose of the Study:

  • To investigate Dvl3 expression in ESCC tissues and cell lines.
  • To determine the functional role of Dvl3 in ESCC progression and tumor properties.

Main Methods:

  • Quantitative analysis of Dvl3 mRNA and protein expression in ESCC tissues (n=50) and normal/hyperplastic tissues.
  • In vitro studies involving Dvl3 silencing (siRNA) in ESCC cell lines to assess proliferation, migration, and apoptosis.
  • In vivo studies using nude mouse xenograft models to evaluate tumor formation.

Main Results:

  • Dvl3 expression was significantly upregulated in ESCC tissues compared to controls.
  • Dvl3 silencing reduced ESCC cell proliferation and migration, while promoting apoptosis.
  • Overexpression of Dvl3 enhanced tumor formation in vivo and correlated with invasion and metastasis.

Conclusions:

  • Dvl3 plays a critical role in promoting ESCC progression, proliferation, and metastasis.
  • Down-regulation of Dvl3 can inhibit tumor growth and induce apoptosis in ESCC.
  • Dvl3 represents a potential therapeutic target and biomarker for ESCC diagnosis and prognosis.

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