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Updated: Feb 1, 2026

Determination of In Vitro and Cellular Turn-on Kinetics for Fluorogenic RNA Aptamers
Published on: August 9, 2022
RNA-aptamers-As targeted inhibitors of protein functions in plants
Inna A Abdeeva1, Liliya G Maloshenok1, Gennady V Pogorelko2
1N.I. Vavilov Institute of General Genetics Russian Academy of Sciences, Gubkina str. 3, Moscow, 119333, Russian Federation.
Abstract:
The scope of RNA-aptamers application is becoming wider and has expanded beyond solely medical use. We propose the use of RNA-aptamers in plants to suppress the functions of individual proteins, thereby achieving resistance to various biotic and abiotic stresses. In current work we experimentally demonstrate the possibility of inhibiting protein activity in N. bentamiana plants by quenching the fluorescence level of GFP (green fluorescent protein) as a result of specifically selected RNA-aptamer binding action.
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