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FST between archaic and present-day samples
Diego Ortega-Del Vecchyo1,2, Montgomery Slatkin3
1Department of Integrative Biology, University of California, Berkeley, CA, 94720-3140, USA.
Heredity
|December 13, 2018
Summary
New population genetics theory explains how genetic differences (FST) between ancient and modern DNA samples depend on both time and distance. This helps understand population replacement events and historical population structures.
Area of Science:
- Population genetics
- Paleogenomics
- Evolutionary biology
Background:
- Analyzing ancient DNA (aDNA) requires population genetics models accounting for temporal and spatial sample separation.
- Wright's FST is a key metric for genetic differentiation, but its interpretation with aDNA is complex.
Observation:
- Fossil DNA yields are increasing, necessitating advanced theoretical frameworks.
- Partial population replacement events create distinct patterns in genetic differentiation over time.
Findings:
- Developed analytic theory linking FST to both temporal and spatial separation of genomes.
- Demonstrated how population replacement causes discontinuities in FST values.
- Showed that in stepping-stone models, FST reflects both distance and time, with time dominating at short distances and isolation-by-distance at long distances.
Implications:
- Provides a new theoretical tool for interpreting genetic data from ancient and modern populations.
- Enables more accurate reconstruction of population histories, including replacement events.
- Applicable to understanding human evolution and migration patterns using archaic European samples.
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