Related Experiment Video
Updated: Feb 1, 2026
03:57
Electrochemotherapy of Tumours
Published on: December 15, 2008
25.1K
Granular Cell Tumour in Stomach: a Case Report
Aleena Jain1, Manjusha Karegar1, Amita Joshi1
1Department of Pathology, Seth GSMC & KEMH, Parel, Mumbai-12, India.
Indian Journal of Surgical Oncology
|December 13, 2018
Summary
Granular cell tumours are rare soft tissue neoplasms, often benign and originating from Schwann cells. This case highlights a gastric granular cell tumour in a young female, successfully treated with wide local excision.
Area of Science:
- Gastroenterology
- Oncology
- Surgical Pathology
Background:
- Granular cell tumours (GCTs) are uncommon soft tissue neoplasms, typically benign, with suspected neural (Schwann cell) origin.
- While GCTs can occur at various sites, their presentation within the gastrointestinal tract is rare, with the esophagus and large intestine being more common than the stomach.
Observation:
- A young female presented with a 3-month history of abdominal discomfort.
- Endoscopic examination revealed a gastric nodule in the body of the stomach.
- Microscopic examination of the biopsy confirmed a granular cell tumour, supported by positive immunohistochemical staining for S100 and CD68.
Findings:
- The diagnosis of a gastric granular cell tumour was established through endoscopic biopsy and confirmed by immunohistochemistry.
- The patient underwent wide local excision of the gastric tumour.
- At a 6-month follow-up, the patient remained asymptomatic, indicating successful treatment.
Implications:
- Endoscopic biopsy is crucial for diagnosing gastric granular cell tumours.
- Wide local excision is considered an adequate surgical treatment for non-malignant gastric granular cell tumours.
- This case underscores the importance of considering rare diagnoses in the stomach, even with atypical presentations.
Related Concept Videos
01:21Stomach pH Regulation
7.2K
The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
7.2K
01:26Stomach Histology
3.2K
The stomach comprises several layers that work together to facilitate digestion and protect the organ. The outermost layer is called the serosa, which provides support and protection to the stomach. The muscularis externa layer is responsible for the mechanical breakdown of food by contracting and moving the stomach. The submucosa layer, located beneath the muscularis externa, contains connective tissue, blood vessels, nerves, and glands that secrete mucus and other substances essential for...
3.2K
01:16Gross Anatomy of the Stomach
3.1K
The human stomach is a vital part of the digestive system, performing multiple functions. It is located within the peritoneum, a serous membrane that lines the abdominal cavity. The stomach plays a central role in processing food substances and interacts with other digestive organs through coordinated digestive processes. The stomach has a characteristic J-shape and is divided into four main regions. The cardia is the first section where the esophagus connects to the stomach and is the entry...
3.1K
01:25Mucosal Barrier of the Stomach
2.3K
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
2.3K
01:25Hormones Secreted by the Stomach
2.7K
Enteroendocrine cells, accounting for only 1% of stomach epithelial cells, play a significant role in digestion and are classified by their digestive hormone secretions.
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
2.7K
01:24Data Reporting and Recording
5.4K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K