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Relationship between Thyroid Function and Kidney Function in Patients with Type 2 Diabetes.
Ying Zhang1, Yang Wang2, Xiao Jun Tao1
1Department of endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
International Journal of Endocrinology
|December 13, 2018
Summary
Elevated thyroid-stimulating hormone (TSH) is linked to reduced kidney function in type 2 diabetes patients. Routine thyroid screening is recommended for managing diabetic kidney disease.
Area of Science:
- Endocrinology
- Nephrology
- Metabolic Disorders
Background:
- Thyroid dysfunction is common in patients with type 2 diabetes (T2D).
- Subclinical thyroid dysfunction may impact kidney function, specifically estimated glomerular filtration rate (eGFR).
Purpose of the Study:
- To investigate the association between TSH levels and eGFR in T2D patients without overt thyroid dysfunction.
- To determine if thyroid function influences kidney health in this population.
Main Methods:
- A cohort study involving 5936 T2D patients.
- Assessment of thyroid function (TSH levels) and kidney function (eGFR, serum creatinine, 24-hour urine albumin excretion).
- Chronic kidney disease (CKD) defined as eGFR < 60 mL/min/1.73 m².
Main Results:
- Subclinical hypothyroidism was associated with lower eGFR, higher urine albumin excretion, and increased CKD incidence compared to euthyroid subjects.
- Patients with TSH levels between 0.55-3.0 μIU/mL had higher eGFR and lower CKD prevalence than those with higher TSH.
- Linear logistic regression revealed a significant negative association between TSH and eGFR (OR: 0.519, p < 0.05) after adjusting for confounders.
Conclusions:
- Elevated TSH is independently associated with decreased eGFR in T2D patients without overt thyroid dysfunction.
- These findings suggest that thyroid function monitoring is crucial for managing kidney health in T2D patients.
- Routine thyroid function tests are recommended for T2D patients to aid in the early detection and management of kidney complications.
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