Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics

Area of Science:

• Neuroscience
• Biomedical Engineering
• Theranostics

Background:

• Brain diseases pose significant public health challenges.
• Brain theranostics is an emerging field for treating various neurological and psychiatric disorders.
• Clinical application of brain theranostics is hindered by factors like the blood-brain barrier and target identification.

Purpose of the Study:

• To review recent advancements in brain theranostics.
• To highlight the role of exosomes in intercellular communication within the brain.
• To discuss the therapeutic potential of graphene quantum dots and advanced transcriptomic approaches for target selection.

Main Methods:

• Literature review of recent studies on brain theranostics.
• Analysis of the role of exosomes in brain cell communication.
• Evaluation of graphene quantum dots for therapeutic effects.
• Exploration of transcriptomics and epitranscriptomics for target identification.

Main Results:

• Exosomes play a crucial role in intercellular communication relevant to brain function and disease.
• Graphene quantum dots show promise for therapeutic applications in the brain.
• Transcriptomic and epitranscriptomic analyses offer novel strategies for precise target selection.
• In vitro and in vivo considerations are critical for successful clinical translation.

Conclusions:

• Addressing challenges such as the blood-brain barrier and target specificity is essential for advancing brain theranostics.
• Intercellular communication, novel nanomaterials, and advanced omics technologies are key areas for future research.
• A comprehensive understanding of these aspects will facilitate the clinical application of brain theranostics.