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NOD2 Arg702Trp Polymorphism in Romanian Patients with Gastric Cancer.
D N Florescu1, D R Tudoraşcu2, F Burada3,4
1Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania.
Current Health Sciences Journal
|December 13, 2018
Summary
The NOD2 Arg702Trp polymorphism (rs2066844) shows no significant association with gastric cancer risk in the Romanian population. Further research is needed to understand the NOD2 gene
Area of Science:
- Genetics
- Oncology
- Molecular Epidemiology
Background:
- Gastric cancer is a significant global health concern.
- Genetic variations may influence individual susceptibility to gastric cancer.
- The NOD2 gene's role in gastric carcinogenesis requires further investigation.
Purpose of the Study:
- To investigate the potential correlation between the NOD2 Arg702Trp (rs2066844) polymorphism and the risk of developing gastric cancer.
- To analyze this association within a Romanian population cohort.
Main Methods:
- A case-control study was conducted with 322 participants (72 gastric adenocarcinoma patients and 250 healthy controls).
- Genomic DNA was isolated from blood leukocytes.
- NOD2 Arg702Trp polymorphism was genotyped using Real-Time PCR with TaqMan probes.
Main Results:
- No statistically significant differences in genotype frequencies were observed between gastric cancer patients and controls (OR 0.45, 95% CI: 0.10 - 2.05).
- Allele frequency comparisons also revealed no significant association (OR 0.46, 95% CI: 0.11 - 2.04).
- The polymorphism showed no correlation with tumor site or histologic type.
Conclusions:
- The NOD2 Arg702Trp polymorphism is not associated with an increased risk of gastric cancer in the studied Romanian population.
- The specific contribution of the NOD2 gene to gastric carcinogenesis remains to be elucidated.
- Further genetic association studies are warranted.
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