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Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis
Published on: August 1, 2019
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Interleukin-22 promotes tumor angiogenesis
Nicholas J Protopsaltis1, Wei Liang1, Eric Nudleman2
1Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093, USA.
Angiogenesis
|December 13, 2018
Summary
Interleukin-22 (IL-22), produced by T helper 17 (TH17) cells, promotes tumor angiogenesis by acting on endothelial cells. Blocking IL-22 inhibits tumor growth and reduces blood vessel formation.
Area of Science:
- Immunology
- Cancer Biology
- Angiogenesis Research
Background:
- T helper 17 (TH17) cells and their cytokine IL-17 are implicated in anti-VEGF therapy resistance.
- TH17 cells recruit myeloid cells that support tumor growth and immunosuppression.
Purpose of the Study:
- To investigate the role of IL-22, a TH17 effector cytokine, in tumor angiogenesis.
- To determine if IL-22 can be a therapeutic target for inhibiting tumor growth.
Main Methods:
- In vitro assays assessing endothelial cell proliferation, survival, and chemotaxis.
- Ex vivo mouse choroid explant model for neovascularization.
- In vivo tumor growth studies with IL-22 blockade using neutralizing antibodies.
Main Results:
- IL-22 directly stimulates endothelial cell proliferation, survival, and migration.
- IL-22 induces neovascularization in a mouse model.
- Blockade of IL-22 significantly reduced tumor growth and tumor microvascular density.
- IL-22 did not show synergistic effects with VEGF.
Conclusions:
- IL-22 is a key mediator of tumor angiogenesis, acting directly on endothelial cells.
- Targeting IL-22 represents a potential therapeutic strategy to inhibit tumor angiogenesis and growth.
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