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The metabolome identity: basis for discovery of biomarkers in neurodegeneration

Julie-Myrtille Bourgognon1, Joern R Steinert1

  • 1MRC Toxicology Unit, University of Leicester, Lancaster Road, Leicester, UK.

Neural Regeneration Research
|December 13, 2018
PubMed

Insights

Identifying metabolic alterations in neurodegenerative diseases, like those caused by misfolded prion protein, can lead to early diagnostic biomarkers. This approach enables timely intervention before irreversible cell dysfunction occurs.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Molecular Biology

Background:

  • Neurodegenerative disorders stem from cellular dysfunction linked to protein-misfolding signaling.
  • Current diagnostics often detect neuropathologies at late, symptomatic stages, limiting treatment efficacy.
  • Early intervention is crucial to halt disease progression before irreversible cell damage.

Purpose of the Study:

  • To review metabolic alterations in neurodegeneration associated with misfolded prion protein.
  • To discuss common toxicity pathways across various neurodegenerative diseases.
  • To highlight the potential of metabolic changes as early diagnostic biomarkers.

Main Methods:

  • Literature review focusing on metabolic alterations in prion protein-induced neurodegeneration.
  • Analysis of common toxicity pathways in different neurodegenerative conditions.
  • Synthesis of findings to identify potential early diagnostic markers.

Main Results:

  • Specific metabolic alterations are associated with neurodegeneration caused by misfolded prion protein.
  • Shared toxicity pathways exist across diverse neurodegenerative diseases.
  • Metabolic changes show promise as early indicators of neurodegenerative disease.

Conclusions:

  • Metabolic alterations are key indicators in neurodegenerative diseases.
  • Identifying common pathways aids in understanding disease mechanisms.
  • Metabolic biomarkers offer a critical opportunity for early diagnosis and intervention in neurodegeneration.
Keywords:
biomarkermetabolomemisfolded proteinneurodegenerationneuroinflammationnitric oxideprion diseaseredox stress

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