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Updated: Feb 1, 2026

Gold Nanoparticle Synthesis
Published on: July 10, 2021
Gold-Catalyzed syn-1,2-Difunctionalization of Ynamides via Nitrile Activation
Rajeshwer Vanjari1, Shubham Dutta1, Manash P Gogoi1
1School of Chemistry , University of Hyderabad , Hyderabad , Telangana India - 500046.
Abstract:
Developed is an unprecedented Au(I)-catalyzed syn-1,2-difunctionalization of ynamides with 2-aminobenzonitriles via nitrile activation. The coupling between ynamides and 2-aminobenzonitriles is explicitly regioselective, providing a straightforward access to 2,4-diamino-substituted quinolines. Density functional theory (DFT) study provides insightful information and rationalizes the reaction pathway. It shows how the synergy between ynamide π-activation and nitrile σ-coordination by the Au(I) catalyst makes the cyclization viable.
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