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Updated: Jun 28, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Regioselective Hydroarylation of Ynamides: A Direct Synthetic Route to Trisubstituted Enamides
Avijit Maity1, Manash Protim Gogoi1, Bishnu Prasad Lima1
1School of Chemistry, University of Hyderabad, Hyderabad 500046, India.
Abstract:
Trisubstituted enamides are commonly found in natural products, pharmaceuticals, and functional materials. A general method for synthesizing trisubstituted enamides is the hydroarylation of ynamides. A metal-free, atom-efficient, regioselective 1,2-hydroarylation of ynamides is herein demonstrated using an arene as a coupling partner. The reaction exhibits a broad substrate scope and tolerates ynamides derived from biologically relevant molecules, highlighting its synthetic utility. In addition, the hydroarylated products can be readily transformed into diverse functional molecules, demonstrating the versatility of this approach.
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