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Updated: Feb 1, 2026
08:12
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
Published on: July 15, 2015
19.8K
Delayed graft function in kidney transplantation
Disha Bahl1, Zaid Haddad2, Asma Datoo3
1University of California, Davis.
Current Opinion in Organ Transplantation
|December 13, 2018
Summary
Delayed graft function (DGF) after kidney transplant is increasing due to organ shortages. Novel immunotherapies targeting ischemia-reperfusion injury and immune responses show promise for preventing DGF and improving graft survival.
Area of Science:
- Nephrology
- Transplantation Immunology
Background:
- Delayed graft function (DGF) poses long-term challenges in kidney transplantation.
- Rising incidence of DGF is linked to increased use of marginal donor organs amid organ scarcity.
- DGF risk factors originate from donor, organ allocation, and recipient factors.
Purpose of the Study:
- To review current understanding and emerging therapies for DGF in kidney transplantation.
- To highlight the impact of DGF on graft survival and acute renal rejection.
- To explore novel therapeutic strategies for mitigating DGF.
Main Methods:
- Review of published data on DGF causes and potential treatments.
- Analysis of ischemia-reperfusion injury (IRI) and immune response mechanisms in DGF.
- Evaluation of novel immunotherapies and other interventions for DGF prevention.
Main Results:
- Ischemia-reperfusion injury (IRI) and immune responses are primary drivers of DGF.
- DGF is associated with a higher incidence of acute renal rejection.
- Several novel therapies are under clinical validation for DGF treatment.
Conclusions:
- Effective therapies are needed to prevent DGF and improve kidney allograft survival.
- Immunotherapies, particularly those inhibiting complement activation, show promise.
- Further research and clinical validation are crucial for advancing DGF prevention strategies.
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