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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

446
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
446
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

407
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Kidney Structure01:45

Kidney Structure

75.2K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.2K
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

3.7K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

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The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
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Related Experiment Video

Updated: Feb 1, 2026

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

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Delayed graft function in kidney transplantation.

Disha Bahl1, Zaid Haddad2, Asma Datoo3

  • 1University of California, Davis.

Current Opinion in Organ Transplantation
|December 13, 2018
PubMed
Summary

Delayed graft function (DGF) after kidney transplant is increasing due to organ shortages. Novel immunotherapies targeting ischemia-reperfusion injury and immune responses show promise for preventing DGF and improving graft survival.

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Related Experiment Videos

Last Updated: Feb 1, 2026

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Area of Science:

  • Nephrology
  • Transplantation Immunology

Background:

  • Delayed graft function (DGF) poses long-term challenges in kidney transplantation.
  • Rising incidence of DGF is linked to increased use of marginal donor organs amid organ scarcity.
  • DGF risk factors originate from donor, organ allocation, and recipient factors.

Purpose of the Study:

  • To review current understanding and emerging therapies for DGF in kidney transplantation.
  • To highlight the impact of DGF on graft survival and acute renal rejection.
  • To explore novel therapeutic strategies for mitigating DGF.

Main Methods:

  • Review of published data on DGF causes and potential treatments.
  • Analysis of ischemia-reperfusion injury (IRI) and immune response mechanisms in DGF.
  • Evaluation of novel immunotherapies and other interventions for DGF prevention.

Main Results:

  • Ischemia-reperfusion injury (IRI) and immune responses are primary drivers of DGF.
  • DGF is associated with a higher incidence of acute renal rejection.
  • Several novel therapies are under clinical validation for DGF treatment.

Conclusions:

  • Effective therapies are needed to prevent DGF and improve kidney allograft survival.
  • Immunotherapies, particularly those inhibiting complement activation, show promise.
  • Further research and clinical validation are crucial for advancing DGF prevention strategies.