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Strategies for Targeted Delivery to the Peripheral Nerve
Kelly A Langert1,2, Eric M Brey3,4
1Department of Veterans Affairs, Research Service, Edward Hines, Jr. VA Hospital, Hines, IL, United States.
Frontiers in Neuroscience
|December 14, 2018
Summary
Targeting the peripheral nervous system (PNS) offers treatments for nerve pain and injury. Bioengineering strategies help overcome the blood-nerve barrier for effective compound delivery to the PNS.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Pharmacology
Background:
- Peripheral nervous system (PNS) drug delivery is crucial for treating neuropathic pain, anesthesia, and nerve injuries.
- Challenges include peripheral neuroanatomy and the restrictive blood-nerve barrier (BNB), hindering therapeutic agent access.
Purpose of the Study:
- To review applications requiring targeted PNS delivery.
- To discuss BNB challenges in these applications.
- To present bioengineering strategies for overcoming these delivery obstacles.
Main Methods:
- Literature review of existing studies on PNS drug delivery.
- Analysis of BNB integrity in various neuropathic conditions.
- Categorization of bioengineering approaches for enhanced PNS targeting.
Main Results:
- Identified key applications for PNS drug delivery, including pain management and nerve repair.
- Detailed the specific barriers posed by the BNB in different pathological states.
- Highlighted diverse bioengineering strategies, such as nanotechnology and focused ultrasound, to improve delivery.
Conclusions:
- Targeted PNS delivery holds significant therapeutic potential.
- Overcoming BNB restrictions via bioengineering is essential for successful treatment.
- This review provides a framework for developing advanced PNS delivery systems.
Keywords:
blood-nerve barrierdrug delivery & targetinginflammatory neuropathynerve graftnerve injuryperipheral nerveMore Related Videos
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