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Antiserum to endotoxin in hemorrhagic shock
E C Pohlson1, A Suehiro, E J Ziegler
1University of Hawaii School of Medicine, Queen's Medical Center, Honolulu 96813.
The Journal of Surgical Research
|November 1, 1988
Summary
Antiserum to Escherichia coli J5 protected rabbits from mortality during hemorrhagic shock. This suggests endotoxemia contributes to mortality in severe hemorrhagic shock, highlighting potential therapeutic targets.
Area of Science:
- Immunology
- Critical Care Medicine
- Microbiology
Background:
- Endotoxemia from gram-negative bacteria increases mortality in shock.
- Escherichia coli J5 antiserum targets core endotoxin determinants.
Purpose of the Study:
- To evaluate the efficacy of Escherichia coli J5 antiserum in reducing mortality in a rabbit model of hemorrhagic shock.
Main Methods:
- Rabbits with coliforms underwent hemorrhagic shock.
- Resuscitation involved J5 antiserum or normal rabbit serum.
- Hemodynamic parameters and survival rates were monitored.
Main Results:
- No significant differences in hemodynamic parameters between groups.
- 60% of J5 antiserum-treated rabbits survived 5 days.
- No control rabbits survived past day 3 (P < 0.019).
Conclusions:
- Escherichia coli J5 antiserum significantly improved survival in hemorrhagic shock.
- Systemic endotoxemia may contribute to morbidity and mortality in severe hemorrhagic shock.