Related Experiment Video

Updated: Feb 1, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Published on: April 29, 2014

17.2K

[Initial Clinical Experience of Nivolumab for Metastatic Renal Cell Carcinoma]

Arinobu Fukunaga1, Toshinari Yamasaki1, Tomoya Okuno1

  • 1The Department of Urology, Kyoto University Hospital.

Hinyokika Kiyo. Acta Urologica Japonica
|December 14, 2018
PubMed

Insights

Nivolumab, an immune checkpoint inhibitor, showed varied efficacy in advanced renal cell carcinoma (RCC) patients. While generally safe with minor side effects, its effectiveness differed across metastatic sites, with lung metastases responding best.

Area of Science:

  • Oncology
  • Immunotherapy

Background:

  • Nivolumab is an immune checkpoint inhibitor approved for advanced renal cell carcinoma (RCC) in Japan.
  • Its mechanism differs from traditional molecular targeted agents, suggesting unique efficacy and adverse event profiles.

Purpose of the Study:

  • To report the initial clinical experience with nivolumab in patients with metastatic RCC.
  • To evaluate the efficacy, safety, and response patterns of nivolumab in advanced RCC.

Main Methods:

  • A cohort of 7 patients with metastatic RCC received nivolumab between December 2016 and September 2017.
  • Efficacy was assessed using immune-related response criteria, with attention to metastatic site variations.
  • Adverse events were monitored throughout the treatment period.

Main Results:

  • Stable disease was observed in 2 patients, and progressive disease in 5 patients.
  • Response varied by metastatic site, with lung metastases showing the best response and brain metastases the worst.
  • Six patients experienced minor adverse events; temporary discontinuation led to complete recovery in two cases.

Conclusions:

  • Nivolumab demonstrated a manageable safety profile in metastatic RCC patients.
  • The drug's efficacy is site-dependent, highlighting the need for tailored treatment strategies.
  • Nivolumab is considered effective and safe for treating metastatic RCC, with distinct response patterns observed.

More Related Videos

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

9.5K
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

14.2K

Related Concept Videos

Initiation of Translation02:33

Initiation of Translation

Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.0K
Initiation of Translation02:33

Initiation of Translation

8.1K
Transcription Initiation01:47

Transcription Initiation

Initiation is the first step of transcription in eukaryotes. Prokaryotic RNA Polymerase (RNAP) can bind to the template DNA and start transcribing. On the other hand, transcription in eukaryotes requires additional proteins, called transcription factors, to first bind to the promoter region in the DNA template. This binding helps recruit the specific RNAP that can assemble on the DNA and start transcription.
The promoters and enhancers and their accessory proteins allow tight regulation of...
21.0K
What is an Experiment?01:12

What is an Experiment?

An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
18.1K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
462
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K