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Updated: Feb 1, 2026

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
Published on: February 14, 2025
Total arch replacement for aortic arch aneurysm with coexisting middle aortic syndrome
Zaiqiang Yu1, Masahito Minakawa1, Norihiro Kondo1
1Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Middle aortic syndrome (MAS) with thoracic aortic aneurysm (TAA) is rare. A challenging one-stage open surgery involving total arch replacement and a femorofemoral bypass successfully treated a complex case, improving patient outcomes.
Area of Science:
- Cardiovascular Surgery
- Vascular Medicine
- Surgical Innovation
Background:
- Middle aortic syndrome (MAS) combined with thoracic aortic aneurysm (TAA) presents a rare and complex clinical challenge.
- Surgical management of concomitant MAS and TAA requires innovative approaches to address extensive aortic disease.
Purpose of the Study:
- To describe a successful one-stage open surgical strategy for a patient with combined MAS and TAA.
- To highlight the efficacy of total arch replacement with a femorofemoral bypass in managing complex aortic pathology.
Main Methods:
- A 69-year-old male patient with a saccular aortic arch aneurysm, shaggy aorta, thoracoabdominal aorta stenosis (MAS), aberrant right subclavian artery, renovascular hypertension, renal dysfunction, and intermittent claudication underwent surgical repair.
- The procedure involved total aortic arch replacement using cardiopulmonary bypass with right axillary artery inflow and a femorofemoral crossover bypass. An additional extra-anatomical bypass from the ascending aortic graft to the femorofemoral bypass was established prior to weaning from bypass.
Main Results:
- Postoperative 3D-CT confirmed the patency of the bypass graft without stenosis.
- The patient experienced an uneventful recovery and was discharged with significant improvements in intermittent claudication, hypertension, and renal function.
Conclusions:
- One-stage open surgery, including graft bypass, can be performed successfully for MAS combined with TAA, mitigating intraoperative and postoperative complications.
- Combined total arch replacement and ascending aorta-to-bifemoral bypass is a viable alternative for treating complex MAS and TAA.
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