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Clinical management of cytotoxic drug overdose
L L Thomas1, M J Mertens, A E von dem Borne
1Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands.
Medical Toxicology and Adverse Drug Experience
|July 1, 1988
Abstract:
In this article the pharmacological management of accidental drug overdose is discussed, with various treatments for overdose proposed, as supported by clinical facts and speculation. Current knowledge is outlined concerning dacarbazine, nitrosourea compounds, melphalan, procarbazine, cyclophosphamide, VP-16.213, l-asparaginase (colaspase), 6-mercaptopurine, mustine (nitrogen mustard), intravenous or intrathecal methotrexate (amethopterin), cytarabine (cytosine arabinoside), fluorouracil and bleomycin.