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Updated: Feb 1, 2026

Profiling Maternal Behavior Responses During Whole-Brain Imaging
Published on: January 24, 2025
Copy number variation profile in noninvasive prenatal testing (NIPT) can identify co-existing maternal malignancies:
Xing Ji1, Fang Chen2, Yafeng Zhou2
1Department of Prenatal Diagnosis, Xin Hua Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, China; Department of Genetics, Shanghai Institute for Pediatric Research, Shanghai, China.
Objective:
The coexistence of maternal malignancy and pregnancy has received increasing attention in Noninvasive prenatal testing (NIPT) studies. Malignancy in pregnant women potentially affects the copy number variation (CNV) profile in NIPT results. Only one case of hematologic cancer has been reported in a Hong-Kong pregnant women, and solid tumors have never been reported in pregnant Chinese women.
Case Report:
The patients with dysgerminoma and cervical cancer showed aberrant chromosomal aneuploidies in NIPT and concordant patterns of genome disruption in tumor tissues. The genomic aberrations in the gastric cancer patient had similar copy number variation pattern of gastric cancer.
Conclusion:
The findings in this study and the literature review further validate the effect of maternal malignancy on the copy number variation profile in NIPT data and strengthen the possibility of detecting malignant tumors with NIPT in the future.
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