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Updated: Feb 1, 2026
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Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
Published on: June 19, 2019
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Defining the Normal Dorsal Contour of the Corpus Callosum with Time
K L Krause1, D Howard2, D R Pettersson2
1Neurological Surgery (K.L.K., D.R., J.T.O.), Oregon Health & Science University, Portland, Oregon.
AJNR. American Journal of Neuroradiology
|December 15, 2018
Summary
Corpus callosum notches, particularly anterior ones, increase with age, suggesting they are acquired. These notches are often associated with pericallosal arteries, potentially influencing their formation.
Area of Science:
- Neuroimaging
- Neuroanatomy
- Radiology
Background:
- Morphological changes in the corpus callosum are linked to neurodevelopmental and psychiatric conditions.
- Focal defects, or notches, on the dorsal corpus callosum surface are not well-understood.
Purpose of the Study:
- Characterize the dorsal contour of the corpus callosum across the lifespan.
- Examine the relationship between contour deviations and adjacent blood vessels.
- Determine if these contour deviations are congenital or acquired.
Main Methods:
- Retrospective review of 1639 sagittal T1-weighted brain MRI studies (ages 0-89).
- Defined a 'notch' as a dorsal concavity ≥1 mm deep.
- Assessed the presence and relationship of pericallosal arteries to notches.
Main Results:
- Identified 1102 notches in 823 studies.
- Anterior notch prevalence and depth correlated positively with age (P < .001, P = .028).
- Posterior notch prevalence correlated negatively with age (P < .001).
- 60% of notches were associated with a pericallosal artery (P < .001).
Conclusions:
- Anterior corpus callosum notch prevalence and depth increase with age, indicating they are likely acquired.
- A significant association exists between corpus callosum notches and pericallosal arteries, suggesting a role in notch formation.
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