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Peripheral Biomarker for Vascular Disorders.

Kaneez Fatima Shad^1,2, Nazar Luqman^2,3, Ann M Simpson¹

¹School of Life Sciences and Centre for Health Technologies, University of Technology Sydney, Broadway, NSW, Australia.

Biomarker Insights

|December 15, 2018

Summary

This summary is machine-generated.

This study suggests a link between serine racemase (SR) activity, D-serine levels, and intima media thickness (IMT). Higher SR activity may indicate increased risk for vascular pathologies like myocardial infarction and stroke.

Keywords:

D-serine NMDA receptors atherosclerosis intima media thickness ischemia peripheral markers serine racemase vascular diseases

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Area of Science:

Cardiovascular Research
Neuroscience
Biochemistry

Background:

Atherosclerosis underlies myocardial infarction (MI) and ischemic stroke.
Increased intima media thickness (IMT) is a marker of arterial wall changes, assessed via ultrasound.
N-methyl-D-aspartate (NMDA) receptors are crucial for brain neurotransmission and implicated in stroke.

Purpose of the Study:

To investigate the relationship between serine racemase (SR) activity, D-serine levels, and IMT.
To explore SR's potential role in predicting vascular pathologies such as MI and stroke.

Main Methods:

Developed methods to estimate D-serine levels in human blood samples.
Correlated estimated D-serine levels with IMT measurements.
Assessed SR activity in relation to IMT and vascular disease markers.

Main Results:

Pilot study indicates a direct relationship between SR, D-serine, and IMT.
Findings suggest SR activity may be a biomarker for atherosclerosis progression.

Conclusions:

SR activity and D-serine levels show a correlation with IMT, a marker of vascular health.
Further research is warranted to determine if SR activity can predict future cardiovascular events like MI and stroke.