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Published on: January 16, 2015
Epigenetic modulation during hippocampal development
Si-Jing Fan1,2, An-Bang Sun2,3, Lian Liu1,2
1Department of Pharmacology, Medical School of Yangtze University, Jingzhou, Hubei 434023, P.R. China.
Abstract:
The hippocampus is located in the limbic system and is vital in learning ability, memory formation and emotion regulation, and is associated with depression, epilepsy and mental retardation in an abnormal developmental situation. Several factors have been found to modulate the development of the hippocampus, and epigenetic modification have a crucial effect in this progress. The present review summarizes the epigenetic modifications, including DNA methylation, histone acetylation, and non-coding RNAs, regulating all stages of hippocampal development, focusing on the growth of Ammons horn and the dentate gyrus in humans and rodents. These modifications may significantly affect hippocampal development and health in addition to cognitive processes.
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