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Mesoporous silica-based nanoplatforms for the delivery of photodynamic therapy agents

Suk Ho Hong1, Yongdoo Choi1

  • 1Biomarker Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 10408 Republic of Korea.

Journal of Pharmaceutical Investigation
|December 15, 2018
PubMed

Insights

Mesoporous silica nanoparticles (MSNs) offer improved properties for photodynamic therapy (PDT) cancer treatment. This review explores MSNs

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Photodynamic therapy (PDT) is a cancer treatment using light, a photosensitizer (PS), and oxygen.
  • Limitations of traditional photosensitizers include poor solubility and tumor specificity.
  • Nanoscale drug delivery systems are being explored to overcome these limitations.

Purpose of the Study:

  • To review the properties of mesoporous silica nanoparticles (MSNs) for photodynamic therapy (PDT).
  • To discuss the latest advancements in using MSNs for PDT applications.
  • To compare different MSN-based approaches in PDT.

Main Methods:

  • Review of existing literature on MSNs in PDT.
  • Analysis of MSN properties relevant to drug delivery and PDT.
  • Comparison of various MSN-based PDT strategies.

Main Results:

  • MSNs possess advantageous characteristics for PDT, including ease of synthesis, loading, functionalization, and biocompatibility.
  • MSNs can effectively encapsulate and deliver photosensitizers, enhancing their solubility and tumor targeting.
  • Diverse strategies for MSN-based PDT are being investigated, showing promising results.

Conclusions:

  • MSNs represent a promising platform for developing advanced photodynamic therapy strategies.
  • Further research into MSN functionalization and targeting can optimize PDT efficacy.
  • MSNs offer a versatile solution to improve the clinical applicability of PDT for cancer treatment.
Keywords:
BiocompatibilityControlled releaseDrug deliveryMesoporous silicaNanocarrierPhotodynamic therapyTheranostic platform

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