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The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
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Related Experiment Video

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Electrochemotherapy of Tumours
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Tumour devascularisation as a potential immunotherapeutic strategy.

Tomas Buchler1, Pavel Vasek2, Radek Spisek3

  • 1Department of Oncology, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.

Oncoimmunology
|December 15, 2018
PubMed
Summary

Complete tumour devascularisation (CTD) is a surgical method that disrupts blood vessels supplying and draining tumours. In animal studies, CTD triggered immune responses, causing distant metastases regression and protective immunity.

Keywords:
Immunotherapycancerdevascularisationischaemiatumour ligation

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Area of Science:

  • Surgical Oncology
  • Immunology
  • Cancer Research

Background:

  • Complete tumour devascularisation (CTD) is a surgical approach.
  • It involves disrupting both the blood vessels supplying (afferent) and draining (efferent) a tumour.
  • This technique leaves the disrupted vasculature in situ.

Purpose of the Study:

  • To investigate the immunological effects of CTD.
  • To determine if CTD can induce regression of distant metastases.
  • To assess the potential for CTD to establish protective immunity.

Main Methods:

  • Surgical disruption of afferent and efferent tumour vasculature.
  • Observation of tumour response in animal models.
  • Assessment of immune responses, including distant metastases and protective immunity.

Main Results:

  • CTD induced significant immune responses in animal models.
  • Regression of distant metastases was observed following CTD.
  • Evidence of protective immunity was noted in some cases.

Conclusions:

  • CTD is a surgical technique that can stimulate anti-tumour immune responses.
  • The immune stimulation may lead to the regression of distant metastases.
  • CTD holds potential for generating protective immunity against cancer recurrence.