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Related Concept Videos

Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

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Updated: Jul 20, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

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Published on: January 5, 2017

[Why don't patients take their nutritional supplements?]

Lorena Arribas Hortigüela1

  • 1. larribas@iconcologia.net.

Nutricion Hospitalaria
|December 15, 2018
PubMed
Summary

Adherence to oral nutritional supplements (ONS) is crucial for malnourished patients but varies widely. Factors like patient, environment, supplement, and prescriber influence intake, necessitating further research for improved patient outcomes.

Area of Science:

  • Nutrition Science
  • Clinical Practice

Background:

  • Oral nutritional supplements (ONS) are vital for malnourished patients.
  • Adherence and compliance are often used interchangeably, impacting nutritional support.
  • Current research on ONS adherence shows significant variability.

Purpose of the Study:

  • To review factors affecting adherence to oral nutritional supplements.
  • To identify limitations in current adherence research.
  • To propose a global approach for improving ONS intake in malnourished patients.

Main Methods:

  • Literature review of studies on ONS adherence.
  • Analysis of factors influencing adherence (patient, environment, supplement, prescriber).
  • Evaluation of research methodologies and limitations.

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Last Updated: Jul 20, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

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Published on: January 5, 2017

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
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Main Results:

  • Adherence measurement methods (objective and subjective) yield diverse results.
  • Patient-related, environmental, supplement-related, and prescriber-related factors impact adherence.
  • Existing research has limitations in scope, quality, and duration.

Conclusions:

  • A comprehensive approach is needed to improve long-term ONS adherence.
  • Further research should focus on specific patient groups, especially malnourished individuals.
  • Investigating organoleptic properties and all influencing factors is essential for optimizing ONS effectiveness.