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Inflammation01:38

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Related Experiment Video

Updated: Feb 1, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Obesity and inflammation.

Jacek Karczewski1, Ewelina Śledzińska2, Alina Baturo2

  • 1Department of Environmental Medicine/Department of Gastroenterology, Human Nutrition and Internal Medicine, Poznan University of Medical Sciences, Fredry 10, Poznan 61-701, Poland.

European Cytokine Network
|December 15, 2018
PubMed
Summary

Obesity causes widespread inflammation in fat tissue, leading to serious health problems like diabetes and cancer. Understanding this inflammation is key to developing new treatments for obesity-related diseases.

Keywords:
adipose tissueinflammationinsulin resistanceobesity

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Area of Science:

  • Metabolic disorders
  • Immunology
  • Pathophysiology

Background:

  • Rising obesity rates correlate with increased incidence of type 2 diabetes mellitus, nonalcoholic fatty liver disease, cancer, and cardiovascular diseases.
  • Adipose tissue inflammation is increasingly recognized as a key driver of obesity-related pathologies.
  • Systemic low-grade inflammation, originating from localized adipose tissue inflammation, contributes significantly to disease development.

Purpose of the Study:

  • To review current knowledge on adipose tissue inflammation in obesity.
  • To elucidate the mechanisms linking obesity to adipose tissue inflammation.
  • To highlight the need for therapeutic strategies targeting obesity-induced inflammation.

Main Methods:

  • Literature review of recent studies on obesity and adipose tissue inflammation.
  • Synthesis of evidence on the molecular and cellular mechanisms involved.
  • Analysis of the link between adipose tissue inflammation and associated comorbidities.

Main Results:

  • Obesity triggers localized inflammation within adipose tissue.
  • This inflammation promotes a chronic, low-grade systemic inflammatory state.
  • Adipose tissue inflammation is a central factor in the pathogenesis of numerous obesity-related diseases.

Conclusions:

  • Adipose tissue inflammation is a critical mediator of obesity-associated diseases.
  • Further research into the mechanisms of adipose tissue inflammation is essential.
  • Targeting adipose tissue inflammation may offer novel therapeutic avenues for obesity and its complications.