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Updated: Feb 1, 2026

Analysis of Coronary Vessels in Cleared Embryonic Hearts
Published on: December 7, 2016
An alternative treatment strategy for large vessel coronary perforations
Iosif Xenogiannis1, Peter Tajti1,2, M Nicholas Burke1
1Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, Minnesota.
Insights
Large vessel coronary perforations during chronic total occlusion interventions can be treated with subintimal recanalization. This technique, involving a subintimal flap, successfully sealed a perforation and achieved hemostasis.
Area of Science:
- Interventional Cardiology
- Vascular Surgery
Background:
- Large vessel coronary perforations are a complication during percutaneous coronary intervention (PCI).
- Standard treatment involves covered stent implantation.
- Chronic total occlusion (CTO) PCI presents unique challenges for managing perforations.
Observation:
- Antegrade attempts to cross a right coronary artery CTO led to guidewire/microcatheter exit and pericardial bleeding.
- Temporary hemostasis was achieved by inflating a balloon proximal to the perforation.
- Retrograde crossing of the CTO was accomplished using epicardial collaterals via a specific tracking technique.
Findings:
- Stent implantation successfully achieved hemostasis.
- A subintimal flap created by the stent likely sealed the perforation site.
- Subintimal recanalization emerged as a potential alternative strategy.
Implications:
- Subintimal recanalization may offer a viable alternative to covered stents for coronary perforations during CTO PCI.
- This approach could expand treatment options for complex coronary artery disease.
- Further research is warranted to establish the safety and efficacy of this technique.
Abstract:
The standard treatment for large vessel coronary perforations is implantation of a covered stent. Antegrade attempts for crossing a right coronary artery chronic total occlusion resulted in guidewire and microcatheter exit with pericardial bleeding. A balloon was inflated proximal to the perforation site to achieve temporary hemostasis. Retrograde crossing of the chronic total occlusion was achieved through an epicardial collateral using the reverse controlled antegrade and retrograde tracking technique. Stent implantation resulted in hemostasis, likely due to creation of a subintimal flap that sealed the perforation site. If technically feasible, subintimal recanalization can be an alternative treatment strategy for coronary perforations occurring during chronic total occlusion percutaneous coronary intervention.
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