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Endometrial Carcinoma, Grossing and Processing Issues: Recommendations of the International Society of Gynecologic
Anais Malpica1, Elizabeth D Euscher, Jonathan L Hecht
1Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M., E.D.E.) Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School (J.L.H.) Department of Pathology, Massachusetts General Hospital and Harvard Medical School (E.O.), Boston, Massachusetts Department of Pathology, Wayne State University, Detroit, Michigan (R.A.F.) Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (C.M.Q.) Department of Cellular Pathology, Barts Health NHS Trust, London (N.S.) Department of Cellular Pathology, Birmingham Women's NHS Trust, Birmingham (L.H.), UK Division of Gynecologic, Breast and Perinatal Pathology, University Hospital, Leipzig (L.C.H.) Institute of Pathology, University Hospital of Tübingen, Tübingen (A.S.), Germany Department of Pathology, Hospital de Oncología Siglo XXI, Mexico City, Mexico City, Mexico (I.A.C.) Department of Pathology, Hospital Universitari de Bellvitge and Hospital Universitari de Arnau de Vilanova, Idibell, Irblleida, and Universitat de Lleida, Ciberonc (X.M.G.) Department of Pathology, Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona (J.O.), Spain Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Alberta, Canada (M.D.) Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (V.P.) Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan (Y.M.) Department of Pathology, Women and Infants Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island (M.R.Q.) Division of Anatomic Pathology, Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania (R.Z.) Department of Pathology, University of California, San Francisco, San Francisco, California (C.Z.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.).
Abstract:
Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during the surgical treatment of patients affected by this disease. This article presents recommendations on how to gross and submit sections for microscopic examination of hysterectomy specimens and other tissues removed during the surgical management of endometrial cancer such as salpingo-oophorectomy, omentectomy, and lymph node dissection-including sentinel lymph nodes. In addition, the intraoperative assessment of some of these specimens is addressed. These recommendations are based on a review of the literature, grossing manuals from various institutions, and a collaborative effort by a subgroup of the Endometrial Cancer Task Force of the International Society of Gynecological Pathologists. The aim of these recommendations is to standardize the processing of endometrial cancer specimens which is vital for adequate pathological reporting and will ultimately improve our understanding of this disease.
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