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Related Concept Videos

Quality Control01:05

Quality Control

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Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
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Quality Assurance01:19

Quality Assurance

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Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
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Quality of Water01:19

Quality of Water

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In concrete preparation, the quality of water is paramount as it affects the strength and durability of the concrete. Potable water is usually preferred; however, it must not have excessive sodium or potassium to prevent compromising the concrete's integrity. Water quality is typically evaluated based on impurities such as dissolved solids, chlorides, and sulfates, and its pH value is ideally between 6 and 8. Even slightly acidic natural water may be acceptable unless it contains harmful...
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Pulse amplitude and quality01:17

Pulse amplitude and quality

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Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
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Testing Water Quality01:14

Testing Water Quality

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When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
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Control System Problem01:21

Control System Problem

431
In an open-loop system, such as a basic thermostat, the poles of the transfer function influence the system's response but do not determine its stability. However, when feedback is introduced to form a closed-loop system, such as an advanced thermostat that adjusts heating based on room temperature, stability is governed by the new poles of the closed-loop transfer function.
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
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Fluorescence Based Primer Extension Technique to Determine Transcriptional Starting Points and Cleavage Sites of RNases In Vivo
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A primer on patient-based quality control techniques.

Tony Badrick1, Mark Cervinski2, Tze Ping Loh3

  • 1RCPA Quality Assurance Programs, Sydney, NSW, Australia.

Clinical Biochemistry
|December 15, 2018
PubMed
Summary
This summary is machine-generated.

Patient-based quality control (QC) methods, long used in hematology, are gaining traction in clinical chemistry. Advances in middleware and understanding of benefits are driving adoption of these QC tools.

Keywords:
Average of normalsPatient-based quality controlQuality control

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Quality Control

Background:

  • Patient-based Quality Control (QC) methods have a long history, established over 50 years ago and routinely used in hematology for 40 years.
  • Practical challenges have limited their widespread adoption in clinical chemistry laboratories.
  • Recent advancements, including middleware availability and recognition of benefits, have spurred interest in patient-based QC.

Purpose of the Study:

  • To review the evolution of patient-based QC techniques.
  • To discuss variations and integration strategies for patient-based QC.

Main Methods:

  • Review of historical patient-based QC approaches, starting with Average of Normals.
  • Discussion of techniques including Moving Average, Moving Median, and Moving Sum of Outliers.
  • Exploration of variations like weighting, transformation, and annealing.

Main Results:

  • Detailed description of various patient-based QC techniques and their development.
  • Analysis of integrating patient-based QC with conventional QC, addressing sub-population issues.

Conclusions:

  • Patient-based QC methods are poised for increased implementation in clinical laboratories.
  • Wider adoption is anticipated as benefits become better understood and middleware facilitates integration.