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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Pulmonary function testing in bronchial asthma.

Masao Tabata, Hajime Kurosawa

Nihon Rinsho. Japanese Journal of Clinical Medicine

|December 15, 2018

Summary

Asthma diagnosis involves assessing airflow limitation and airway hyperresponsiveness. Monitoring peak expiratory flow (PEF) and using bronchoprovocation tests aid in diagnosis and management.

Area of Science:

Pulmonology
Respiratory Medicine
Clinical Diagnostics

Background:

Asthma is defined by variable airflow limitation and airway hyperresponsiveness.
Reversibility of airflow limitation after bronchodilator use is a key characteristic.
Mild asthma may not exhibit significant airflow reversibility.

Purpose of the Study:

To outline the key features of asthma-related lung function impairment.
To highlight the role of peak expiratory flow (PEF) monitoring in asthma assessment.
To explain the diagnostic utility of bronchoprovocation testing in asthma.

Main Methods:

Assessment of airflow limitation and its reversibility.
Self-monitoring of peak expiratory flow (PEF) and its circadian variation.

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Direct measurement of airway hyperresponsiveness via bronchoprovocation testing (methacholine/histamine).

Main Results:

Airflow limitation, often reversible with bronchodilators, characterizes asthma.
Circadian PEF variations can indicate underlying airway hyperresponsiveness.
Bronchoprovocation testing directly quantifies airway hyperresponsiveness.

Conclusions:

Asthma diagnosis relies on airflow limitation, variability, and hyperresponsiveness.
PEF monitoring offers a practical method for assessing asthma control.
Bronchoprovocation testing is crucial for accurate diagnosis, severity assessment, and therapy response evaluation in specific asthma cases.