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Updated: Feb 1, 2026

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Adipose tissue dendritic cells in steady-state
Claire E Macdougall1, M Paula Longhi1
1William Harvey Research Institute, Barts and the London, Queen Mary University of London, London, UK.
Abstract:
Healthy white adipose tissue (WAT) participates in regulating systemic metabolism, whereas dysfunctional WAT plays a prominent role in the development of obesity-associated co-morbidities. Tissue-resident immune cells are important for maintaining WAT homeostasis, including conventional dendritic cells (cDCs) which are critical in the initiation and regulation of adaptive immune responses. Due to phenotypic overlap with other myeloid cells, the distinct contribution of WAT cDCs has been poorly understood. This review will discuss the contribution of cDCs in the maintenance of WAT homeostasis. In particular, the review will focus on the metabolic cross-talk between cDCs and adipocytes that regulates local immune responses during physiological conditions.
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