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Updated: Feb 1, 2026

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
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Cardio-omentopexy Reduces Cardiac Fibrosis and Heart Failure After Experimental Pressure Overload

Jian Wang1, Qing-Jun Zhang2, Timothy J Pirolli1

  • 1Department of Thoracic and Cardiovascular Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

The Annals of Thoracic Surgery
|December 16, 2018
PubMed

Insights

Cardio-omentopexy significantly improved heart function in a rat model of left ventricular hypertrophy (LVH). This procedure reduced cardiac dilation, improved contractility, and decreased fibrosis, offering a potential therapeutic strategy for heart disease.

Area of Science:

  • Cardiovascular Surgery
  • Regenerative Medicine
  • Cardiac Physiology

Background:

  • The pedicled greater omentum shows promise in treating ischemic heart disease.
  • The efficacy of cardio-omentopexy in pressure overload-induced left ventricular hypertrophy (LVH) remains unexplored.

Purpose of the Study:

  • To investigate the impact of cardio-omentopexy on a rat model of LVH.
  • To assess the effects of omentopexy on cardiac structure, function, and molecular markers in LVH.

Main Methods:

  • Left ventricular hypertrophy (LVH) was induced in rats by ascending aortic banding.
  • Survivors underwent either cardio-omentopexy or sham surgery.
  • Echocardiography, gene expression, and histological analyses were performed 10 weeks post-procedure.

Main Results:

  • Cardio-omentopexy significantly reduced LV end-systolic diameter, cardiomyocyte size, and myocardial fibrosis compared to controls.
  • LV ejection fraction was preserved in the cardio-omentopexy group.
  • Myocardial capillary density was increased, and fibrotic markers were decreased post-omentopexy.

Conclusions:

  • Cardio-omentopexy effectively mitigated cardiac dilation, contractile dysfunction, and fibrosis in a pressure overload LVH model.
  • The procedure maintained molecular indicators of cardiac contractile function.
  • Omentopexy presents a potential therapeutic approach for managing LVH.
Abstract

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