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Updated: Feb 1, 2026

Monitoring Changes in the Intracellular Calcium Concentration and Synaptic Efficacy in the Mollusc Aplysia
Published on: July 15, 2012
Synergistic agent and intracellular calcium, a successful partnership in the optimization of insecticide efficacy
Caroline Deshayes1, Eléonore Moreau1, Javier Pitti-Caballero1
1Laboratoire Signalisation Fonctionnelle des Canaux Ioniques et Récepteurs (SiFCIR), UPRES-EA 2647, USC INRA 1330, SFR 4207 QUASAV, UFR Sciences, Université d'Angers, 2 Boulevard Lavoisier, F-49045 Angers Cedex, France.
Abstract:
Integrated Pest Management and Integrated Vector Management worldwide are developed in agriculture and public health to counteract and limit the exponential increasing development of insect resistance to insecticides. However, facing the predominance of some resistant populations, new strategies are urgently needed to target resistant insects. An innovative approach lies in the optimization of commonly used insecticides when combined with chemical or biological synergistic agents. By an increase of intracellular calcium concentration followed by activation of calcium-dependant signalling pathways, the synergistic agents are able to indirectly increase target sites sensitivity to insecticide by inducing conformational change. The synergistic agents are of great interest in optimizing the efficacy of insecticides and in overcoming resistance mechanisms.
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