Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transfer Function in Control Systems01:21

Transfer Function in Control Systems

1.6K
The transfer function is a fundamental concept in the analysis and design of linear time-invariant (LTI) systems. It offers a concise way to understand how a system responds to different inputs in the frequency domain. It serves as a bridge between the time-domain differential equations that describe system dynamics and the frequency-domain representation that facilitates easier manipulation and analysis.
To derive the transfer function, consider a general nth-order linear time-invariant...
1.6K
Combinatorial Gene Control02:33

Combinatorial Gene Control

9.7K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.7K
What is Gene Expression?01:42

What is Gene Expression?

196.7K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.7K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

26.4K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
26.4K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

110.9K
Overview
110.9K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.5K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pediatric hepatic pseudoaneurysm formation following blunt and penetrating abdominal trauma: a 5-year retrospective analysis.

Journal of trauma and injury·2026
Same author

EZH2 and intracellular Ca<sup>2+</sup> signals interdependently coordinate alloreactive and CAR-T-cell responses.

Cellular & molecular immunology·2026
Same author

Metabolic Reprograming in Cancer.

Journal of cellular physiology·2025
Same author

Targeting TRPC channels for control of arthritis-induced bone erosion.

Science advances·2025
Same author

TPC2 controls MITF expression and metastasis in melanoma.

Cell calcium·2024
Same author

Molecular Regulation of Bone Turnover in Juvenile Idiopathic Arthritis: Animal Models, Cellular Features and TNFα.

Frontiers in bioscience (Landmark edition)·2024

Related Experiment Video

Updated: Feb 1, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
07:30

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

7.6K

EGR-mediated control of STIM expression and function.

Christina K Go1, Scott Gross1, Robert Hooper1

  • 1Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA.

Cell Calcium
|December 17, 2018
PubMed
Summary

Calcium (Ca2+) signals regulate cell functions. This review explores how Early Growth Response (EGR) transcription factors control Stromal Interaction Molecule 1 (STIM1), impacting cellular calcium (Ca2+) entry and cell fate.

Keywords:
Calcium signalingEarly growth response factorsPMCASTIM1Store-operated calcium entry

More Related Videos

RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem
09:44

RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem

Published on: December 21, 2015

21.5K
Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
06:58

Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs

Published on: May 18, 2022

1.5K

Related Experiment Videos

Last Updated: Feb 1, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
07:30

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

7.6K
RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem
09:44

RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem

Published on: December 21, 2015

21.5K
Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
06:58

Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs

Published on: May 18, 2022

1.5K

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Calcium (Ca2+) acts as a crucial second messenger in cellular processes like differentiation, proliferation, and cell death.
  • Ca2+ signals are orchestrated by channels, pumps, and transporters on the plasma membrane (PM) and endoplasmic reticulum (ER).
  • Variations in Ca2+ homeostasis protein expression influence Ca2+ signal dynamics and cell fate.

Purpose of the Study:

  • To review the role of Early Growth Response (EGR) transcription factors.
  • To elucidate the transcriptional regulation of Stromal Interaction Molecule 1 (STIM1) by EGR factors.
  • To understand the impact on Ca2+ entry and cellular function.

Main Methods:

  • Literature review of studies on EGR transcription factors and STIM1.
  • Analysis of molecular mechanisms regulating STIM1 expression.
  • Examination of the consequences of STIM1 regulation on Ca2+ homeostasis.

Main Results:

  • EGR transcription factors play a significant role in regulating STIM1 expression.
  • STIM1 is a key regulator of Ca2+ entry in various cell types.
  • The EGR-STIM1 axis influences cellular responses and cell fate.

Conclusions:

  • EGR factors are critical regulators of the Ca2+ entry pathway via STIM1.
  • Understanding this regulatory axis provides insights into cell signaling and disease.
  • Targeting the EGR-STIM1 interaction may offer therapeutic potential.