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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
Host-Directed Drug Therapies for Neglected Tropical Diseases Caused by Protozoan Parasites
Sanjay Varikuti1, Bijay Kumar Jha2, Greta Volpedo1,3
1Department of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Abstract:
The neglected tropical diseases (NTDs) caused by protozoan parasites are responsible for significant morbidity and mortality worldwide. Current treatments using anti-parasitic drugs are toxic and prolonged with poor patient compliance. In addition, emergence of drug-resistant parasites is increasing worldwide. Hence, there is a need for safer and better therapeutics for these infections. Host-directed therapy using drugs that target host pathways required for pathogen survival or its clearance is a promising approach for treating infections. This review will give a summary of the current status and advances of host-targeted therapies for treating NTDs caused by protozoa.
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