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Injection therapy for impotence.

E D Kursh1, D R Bodner, M I Resnick

  • 1Case Western Reserve University School of Medicine, Cleveland, Ohio.

The Urologic Clinics of North America
|November 1, 1988
PubMed
Summary
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Intracavernosal injections of vasoactive drugs, like papaverine, effectively treat impotence in many men. Careful dosing minimizes risks such as priapism, with most patients achieving satisfactory erections.

Area of Science:

  • Urology
  • Pharmacology

Background:

  • Impotence, or erectile dysfunction, affects men of all ages and causes.
  • Vasoactive drug injections offer a treatment option for specific patient groups.

Purpose of the Study:

  • To evaluate the efficacy and safety of intracavernosal vasoactive drug injections for treating impotence.

Main Methods:

  • Utilized papaverine alone or in combination with phentolamine for injections.
  • Administered trial injections in-office, titrating dosage to minimize priapism.
  • Monitored for efficacy (erection) and side effects (priapism, bruising, nodules).

Main Results:

  • Achieved satisfactory erections in 65-100% of patients over 2 years.
  • Minimal side effects reported, including bruising and nodule formation.

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  • Priapism, though occurring, responded well to standard treatments.

    • Conclusions:

    • Intracavernosal vasoactive drug injections are effective for selected patients with organic, mixed, and some psychogenic impotence.
    • Careful dose titration is crucial for minimizing priapism risk.
    • While effective, high dropout rates suggest potential for improved patient management or counseling.