In Vitro Immune Organs-on-Chip for Drug Development: A Review

Area of Science:

• Biomedical Engineering
• Drug Discovery
• Immunotoxicology

Background:

• Drug development lacks sensitive immunotoxicity assessment methods, contributing to high attrition rates.
• Organ-on-chip and body-on-chip technologies offer in vivo simulating environments for physiological studies.
• There is a growing need for advanced models to predict systemic drug effects.

Purpose of the Study:

• To review existing biomimetic immune organ-on-chip models.
• To highlight their relevance in drug development and discovery.
• To emphasize the necessity of comprehensive immune system-on-chip models.

Main Methods:

• Review of current literature on immune organ-on-chip technologies.
• Analysis of the physiological relevance of these models for drug testing.
• Discussion on the potential of integrated immune system-on-chip models.

Main Results:

• Existing immune organ-on-chip models show promise in simulating immune functions.
• These models can provide valuable insights into drug-induced immune responses.
• The development of comprehensive immune system models is crucial for accurate prediction.

Conclusions:

• Biomimetic immune organ-on-chip models are vital for improving drug candidate evaluation.
• Such models can enhance the success rate of novel drugs in clinical trials.
• Implementing advanced immune models can significantly reduce drug development costs and attrition.