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The IgA mucosal immune system.

M E Lamm1

  • 1Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|November 1, 1988
PubMed
Summary
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Secretory IgA forms a crucial mucosal immune barrier, inhibiting antigen uptake. Its local production and regulation by T cells influence host defense and disease pathogenesis.

Area of Science:

  • Immunology
  • Mucosal Immunity
  • Immunophysiology

Background:

  • The mucosal immune system protects against pathogen entry via mucous membranes.
  • Secretory IgA is the primary antibody at mucosal surfaces.
  • Understanding IgA's role is key to mucosal defense and disease.

Purpose of the Study:

  • To review the immunophysiology of the mucosal immune system.
  • To detail the production and function of secretory IgA.
  • To explore the implications of IgA regulation in host defense and disease.

Main Methods:

  • Review of existing literature on mucosal immunology.
  • Analysis of secretory IgA production and transport mechanisms.
  • Examination of T cell regulation of antibody synthesis.

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Main Results:

  • Secretory IgA is locally produced by plasma cells originating from stimulated lymphoid precursors.
  • Secretory IgA binds epithelial receptors, forming a nonphlogistic barrier in secretions.
  • Regulatory T cells facilitate IgA production while suppressing other antibody classes like IgG.

Conclusions:

  • Differential regulation of antibody classes and interconnected mucosal sites are vital for host defense.
  • Mucosal immune responses impact the pathogenesis of diseases such as IgA nephropathy.
  • Insights into IgA function inform immunization strategies for mucosal immunity.