Aspirin: are patients actually taking it?-A quality assessment study

Area of Science:

• Orthopedic Surgery
• Pharmacology
• Vascular Medicine

Background:

• Deep venous thromboembolism (DVT) is a significant risk following lower extremity arthroplasty.
• Aspirin is commonly prescribed for DVT prophylaxis in these patients.
• Patient adherence to prescribed DVT prophylaxis regimens is crucial for effective prevention.

Purpose of the Study:

• To evaluate patient adherence to aspirin prophylaxis for DVT after total lower extremity arthroplasty.
• To identify factors influencing nonadherence to aspirin DVT prophylaxis.

Main Methods:

• A cross-sectional study surveyed 101 patients post-total hip or knee replacement.
• Adherence to a 6-week, twice-daily aspirin regimen (325 mg) was assessed at the 6-week follow-up.
• Patients were surveyed regarding their aspirin use and reasons for discontinuation.

Main Results:

• 52% of patients were nonadherent to the aspirin DVT prophylaxis regimen.
• Reasons for nonadherence included perceived lack of need, side effects, and uncertainty about duration.
• One patient experienced a calf DVT; no pulmonary embolism occurred.

Conclusions:

• A significant proportion of patients do not complete their prescribed aspirin regimen for DVT prophylaxis.
• Clearer communication regarding the duration of aspirin therapy is needed.
• Standardized medication instructions pre- and post-operatively may improve adherence.