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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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External Anatomy of the Kidney01:21

External Anatomy of the Kidney

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The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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Related Experiment Video

Updated: Jan 31, 2026

A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
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A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys

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[Hyperhomocysteinemia and kidney diseases].

Yun-Feng Zhou1, You-Fei Guan2

  • 1Medical Research Center, Physiology Department of Basic Medical College, Shenzhen University Health Science Center, Shenzhen 518060, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|December 19, 2018
PubMed
Summary

High homocysteine (HHcy) levels are linked to various health issues, including kidney diseases. Understanding this connection may reveal new treatment strategies for kidney conditions.

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Area of Science:

  • Biochemistry
  • Nephrology
  • Metabolic Disorders

Background:

  • Homocysteine (Hcy) is a key intermediate in methionine metabolism.
  • Hyperhomocysteinemia (HHcy) is defined as elevated plasma Hcy (>16 μmol/L), often due to metabolic dysfunction.
  • HHcy is associated with numerous conditions, including cardiovascular, neurodegenerative, and kidney diseases.

Purpose of the Study:

  • This review aims to consolidate the current understanding of the relationship between HHcy and kidney diseases.
  • To explore the potential of targeting HHcy for novel kidney disease prevention and treatment strategies.

Main Methods:

  • Literature review and synthesis of existing research on HHcy and renal pathology.
  • Analysis of studies correlating plasma Hcy levels with various kidney disease markers and outcomes.

Main Results:

  • The review summarizes evidence linking HHcy to diverse kidney conditions.
  • Specific mechanisms by which HHcy may impact renal function are discussed.

Conclusions:

  • Hyperhomocysteinemia is significantly correlated with the development and progression of kidney diseases.
  • Further research into HHcy's role in nephrology may offer new therapeutic avenues.