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[Hyperhomocysteinemia and kidney diseases]

Yun-Feng Zhou1, You-Fei Guan2

  • 1Medical Research Center, Physiology Department of Basic Medical College, Shenzhen University Health Science Center, Shenzhen 518060, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|December 19, 2018
PubMed

Insights

High homocysteine (HHcy) levels are linked to various health issues, including kidney diseases. Understanding this connection may reveal new treatment strategies for kidney conditions.

Area of Science:

  • Biochemistry
  • Nephrology
  • Metabolic Disorders

Background:

  • Homocysteine (Hcy) is a key intermediate in methionine metabolism.
  • Hyperhomocysteinemia (HHcy) is defined as elevated plasma Hcy (>16 μmol/L), often due to metabolic dysfunction.
  • HHcy is associated with numerous conditions, including cardiovascular, neurodegenerative, and kidney diseases.

Purpose of the Study:

  • This review aims to consolidate the current understanding of the relationship between HHcy and kidney diseases.
  • To explore the potential of targeting HHcy for novel kidney disease prevention and treatment strategies.

Main Methods:

  • Literature review and synthesis of existing research on HHcy and renal pathology.
  • Analysis of studies correlating plasma Hcy levels with various kidney disease markers and outcomes.

Main Results:

  • The review summarizes evidence linking HHcy to diverse kidney conditions.
  • Specific mechanisms by which HHcy may impact renal function are discussed.

Conclusions:

  • Hyperhomocysteinemia is significantly correlated with the development and progression of kidney diseases.
  • Further research into HHcy's role in nephrology may offer new therapeutic avenues.

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