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Expression Pattern of Long Non-coding RNAs in Schizophrenic Patients
Mohammad Reza Safari1, Alireza Komaki1, Shahram Arsang-Jang2
1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Cellular and Molecular Neurobiology
|December 19, 2018
Summary
This study found specific long non-coding RNAs (lncRNAs) are altered in schizophrenia patients. Certain lncRNAs like GAS5 show diagnostic potential in female schizophrenia cases.
Area of Science:
- Neuroscience
- Genetics
- Molecular Biology
Background:
- Long non-coding RNAs (lncRNAs) are implicated in neurological disorders.
- Schizophrenia pathogenesis involves complex genetic and molecular factors.
- Dysregulation of specific lncRNAs may contribute to schizophrenia development.
Purpose of the Study:
- To investigate the expression levels of seven lncRNAs in peripheral blood of schizophrenia patients.
- To compare lncRNA expression between patients and healthy controls.
- To explore potential diagnostic utility of lncRNAs in schizophrenia.
Main Methods:
- Quantitative real-time PCR was used to measure peripheral blood expression of seven lncRNAs.
- Comparison of lncRNA expression between schizophrenic patients and sex- and age-matched controls.
- Statistical analyses including regression and correlation were performed to assess associations with schizophrenia, age, and sex.
Main Results:
- FAS-AS1, PVT1, and TUG1 were significantly downregulated in schizophrenic patients.
- THRIL was significantly upregulated in schizophrenic patients.
- GAS5 showed high sensitivity and specificity for diagnosing schizophrenia in female patients, with other lncRNAs showing sex-specific associations.
Conclusions:
- The study provides evidence for the involvement of lncRNAs in schizophrenia pathogenesis.
- Specific lncRNAs may serve as potential peripheral biomarkers for schizophrenia, particularly GAS5 in females.
- Further research is needed to validate lncRNAs as reliable biomarkers for schizophrenia.
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