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Updated: Jan 31, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Association between fragmented QRS complexes and left ventricular dysfunction in healthy smokers
Adil Bayramoğlu1, Hakan Taşolar2, Osman Bektaş1
1Faculty of Medicine, Department of Cardiology, Ordu University, Ordu, Turkey.
Fragmented QRS (fQRS) indicates subclinical left ventricle dysfunction in smokers, linked to smoking duration and intensity. This finding highlights fQRS as a key indicator for early detection of smoking-related cardiac issues.
Area of Science:
- Cardiology
- Cardiovascular Diseases
- Medical Diagnostics
Background:
- Smoking is a significant risk factor for cardiovascular diseases.
- It can independently cause myocardial damage, even without coronary artery disease.
- Fragmented QRS (fQRS) is recognized as a marker for myocardial fibrosis.
Purpose of the Study:
- To investigate the association between smoking and subclinical left ventricle dysfunction.
- To evaluate the utility of fQRS as an indicator of myocardial fibrosis and dysfunction in smokers.
- To explore the relationship between smoking intensity/duration and cardiac parameters.
Main Methods:
- A study involving 230 healthy individuals (130 smokers, 100 non-smokers) aged 18-40 years.
- Smokers were further classified based on the presence or absence of fQRS.
- Left ventricle global longitudinal strain (LV-GLS) and E/SRe ratio were measured using speckle-tracking echocardiography.
Main Results:
- Smokers exhibited significant differences in E/SRe, LV-GLS, and fQRS compared to non-smokers.
- A higher pack-year history was observed in smokers with fQRS.
- Negative correlation between pack-year history and LV-GLS; positive correlation with E/SRe.
Conclusions:
- Fragmented QRS (fQRS) can identify subclinical systolic and diastolic dysfunction in smokers.
- Left ventricle dysfunction in smokers is correlated with the duration and intensity of smoking.
- fQRS serves as a valuable parameter for assessing smoking-induced cardiac changes.
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