Related Experiment Video
Updated: Jan 31, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Gender Differences in Patient-Reported Outcomes Among Adults With Atherosclerotic Cardiovascular Disease
Victor Okunrintemi1, Javier Valero-Elizondo2, Benjamin Patrick3
11 Department of Internal Medicine East Carolina University Greenville NC.
Women with atherosclerotic cardiovascular disease (ASCVD) report worse healthcare experiences and lower quality of life than men. This highlights critical gender disparities in ASCVD patient outcomes needing further investigation.
Area of Science:
- Cardiology
- Public Health
- Health Services Research
Background:
- Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of death in women, yet gender differences in patient-reported outcomes are understudied.
- Positive patient experiences and quality of life are linked to better health outcomes, but specific gender disparities in ASCVD are not well understood.
Purpose of the Study:
- To compare gender differences in patient-centered outcomes, including patient experience, health perception, and quality of life, among individuals diagnosed with ASCVD.
Main Methods:
- Analysis of data from the 2006-2015 Medical Expenditure Panel Survey, a national US sample.
- Inclusion of adults (≥18 years) with ASCVD, identified via ICD-9 codes or self-report.
- Use of linear and logistic regression, adjusted for demographics, socioeconomic status, and comorbidities, to compare outcomes by gender.
Main Results:
- Women with ASCVD reported poorer patient-provider communication (OR 1.25), lower healthcare satisfaction (OR 1.12), worse health perception (OR 1.15), and lower quality of life compared to men.
- Women also showed lower use of aspirin and statins and higher odds of frequent Emergency Department visits (≥2/year).
Conclusions:
- Women with ASCVD experience significantly poorer patient-reported outcomes, including diminished quality of life and health perception, compared to men.
- These findings underscore critical gender-specific disparities in healthcare quality and delivery for ASCVD patients, necessitating further research and targeted interventions.
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