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Updated: Jan 31, 2026

Measuring Phagocytosis of Aspergillus fumigatus Conidia by Human Leukocytes using Flow Cytometry
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Measuring Phagocytosis of Aspergillus fumigatus Conidia by Human Leukocytes using Flow Cytometry

Published on: December 7, 2019

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Trends in Azole Resistance in Aspergillus fumigatus, the Netherlands, 1994-2016

Jochem B Buil, Eveline Snelders, Laura Bedin Denardi

    Emerging Infectious Diseases
    |December 19, 2018
    PubMed

    Insights

    Azole resistance in Aspergillus fumigatus has significantly increased in the Netherlands since the late 1990s. This trend highlights a growing challenge in treating fungal infections, requiring further investigation into resistance mechanisms.

    Area of Science:

    • Medical Mycology
    • Antimicrobial Resistance
    • Clinical Microbiology

    Background:

    • Investigated the prevalence of azole resistance in Aspergillus fumigatus, a common fungal pathogen.
    • Focused on data from a tertiary reference hospital in the Netherlands spanning 1994-2016.
    • Examined trends in resistance over distinct 5-year periods.

    Discussion:

    • Observed a notable rise in patient-adjusted azole resistance proportions over the study period.
    • Documented a significant increase from 0.79% (1996-2001) to 7.17% (2007-2011).
    • Acknowledged substantial year-to-year variations in resistance rates, indicating complex epidemiological dynamics.

    Key Insights:

    • Azole resistance in Aspergillus fumigatus shows a clear upward trend in the Netherlands.
    • The proportion of resistance increased substantially, reaching over 7% in recent periods.
    • Fluctuations between years suggest multifactorial influences on resistance development.

    Outlook:

    • Further research is needed to understand the drivers of increasing azole resistance.
    • Implications for antifungal treatment strategies and patient outcomes require careful consideration.
    • Monitoring resistance patterns is crucial for effective management of invasive fungal infections.
    Keywords:
    Aspergillus fumigatusantimicrobial resistanceaspergillosisazole resistanceepidemiologyfungithe Netherlands

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