Related Experiment Video

Updated: Jan 31, 2026

Measuring Phagocytosis of Aspergillus fumigatus Conidia by Human Leukocytes using Flow Cytometry
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Measuring Phagocytosis of Aspergillus fumigatus Conidia by Human Leukocytes using Flow Cytometry

Published on: December 7, 2019

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Emerging threat of triazole-resistant Aspergillus fumigatus

Jeffrey M Rybak1, Jarrod R Fortwendel1, P David Rogers1

  • 1Department of Clinical Pharmacy and Translational Sciences, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, TN, USA.

The Journal of Antimicrobial Chemotherapy
|December 19, 2018
PubMed

Insights

Invasive aspergillosis, caused by Aspergillus fumigatus, is a serious threat. Emerging triazole resistance complicates treatment, necessitating new therapeutic strategies for these difficult-to-treat infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Invasive aspergillosis poses a significant threat to immunocompromised individuals, causing over 200,000 life-threatening infections annually.
  • Aspergillus fumigatus is the primary causative agent, responsible for over 60% of invasive aspergillosis cases.
  • Current treatments rely on mould-active triazoles and amphotericin B, but resistance is emerging.

Purpose of the Study:

  • To highlight the growing challenge of triazole-resistant Aspergillus fumigatus.
  • To emphasize the urgent need for understanding the mechanisms of resistance.
  • To underscore the necessity for developing novel therapeutic approaches.

Main Methods:

  • Review of current literature on invasive aspergillosis and Aspergillus fumigatus.
  • Analysis of known resistance mechanisms, including cyp51A mutations and gene overexpression.
  • Identification of gaps in clinical knowledge and treatment options.

Main Results:

  • Triazole resistance in Aspergillus fumigatus is a global concern, complicating treatment.
  • Known resistance mechanisms include mutations and overexpression of the cyp51A gene and efflux pump genes.
  • A significant portion of triazole resistance remains unexplained, and clinical data on treating resistant infections is scarce.

Conclusions:

  • The emergence of triazole-resistant Aspergillus fumigatus presents a critical public health challenge.
  • Further research is essential to elucidate resistance mechanisms and guide the development of new antifungal therapies.
  • Improved treatment strategies are urgently needed to reduce the high mortality associated with these infections.

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