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Updated: Jan 31, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
Published on: April 6, 2016
A Randomized Trial to Evaluate the Effect of Toric Versus Spherical Contact Lenses on Vision and Eyestrain
David A Berntsen1, Stephanie M Cox, Katherine M Bickle
1The Ocular Surface Institute (D.A.B., D.R.P.), University of Houston College of Optometry, Houston, TX; University of Alabama at Birmingham School of Optometry (S.M.C., J.J.N.), Birmingham, AL; The Ohio State University College of Optometry (K.M.B.), Columbus, OH; Alcon Laboratories (J.H.M.), Fort Worth, TX; Department of Biomedical Engineering (S.H.S.), University of Rochester, Rochester, NY; and Johnson & Johnson Vision Care, Inc (B.K.L., K.O.L.), Jacksonville, FL.
Objectives:
To compare the effect of toric versus spherical soft contact lenses on objective measures of visual performance using visual acuity and electromyography of the orbicularis oculi muscle.
Methods:
Current soft contact lens wearers with -0.75 to -1.75 D astigmatism in each eye were binocularly fitted with toric (1-Day ACUVUE MOIST for astigmatism) and spherical (1-Day ACUVUE MOIST) contact lenses in random order. After each fitting and at 1-week follow-up, high- and low-contrast visual acuities were measured. Electromyography was used to objectively evaluate eyestrain. Linear mixed models were used to assess differences between toric and spherical contact lenses.
Results:
The mean age (±SD) of the 60 participants was 27.5±5.0 years, spherical refractive error was -3.68±2.01 D, and cylinder was -1.28±0.36 D. High- and low-contrast visual acuities with toric lenses were better than with spherical lenses at both fitting (toric high-contrast: -0.065±0.078 and low-contrast: 0.133±0.103 vs. spherical high-contrast: 0.001±0.104 and low-contrast: 0.224±0.107) and follow-up (toric high-contrast: -0.083±0.087 and low-contrast: 0.108±0.107 vs. spherical high-contrast: -0.015±0.095 and low-contrast: 0.211±0.104) (all P<0.0001). Electromyography-measured eyestrain was less with toric versus spherical contact lenses at fitting (least-square ratio of toric over spherical=0.72; P=0.0019) but not at follow-up (ratio=0.86; P=0.11).
Conclusion:
These results suggest that toric contact lenses provided improved objective measures of vision in a low-to-moderate astigmatic population.
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